Pratiksha Shahi and D. Sharma

Medicinal plants are important substances for the study of their traditional uses through the verification of pharmacological effects and can be natural composite source that act as new anti-infectious agents. Medicinal plants have been a source of novel drug compound. Green pharmacy may become the base for the base of medicine by providing a pharmacophore which could be used for the development new drugs with novel mechanisms of action. A number of medicine plants have been screened for antimicrobial activity in recent years and efforts have been done to identify their active constituents. The extracts possessing bioactivity are essentially evaluated for toxicity and the extracts are usually tested for short or long term toxicity in animal models. Plant derived products have made large contribution to human health and wellbeing. A number of medicine plants have been screened for antimicrobial activity in recent years and efforts have been done to identify their active constituents. Garlic has an important dietary and medicinal role for centuries. Our work was focused on isolation of bioactive compounds from Garlic and evaluation of its antimicrobial activity on pathogenic bacterial strains. Analysis of antimicrobial activity was done by Disc diffusion technique on Mueller Hinton Agar against Proteus vulgaris, Escherichia coli, Streptococcus mutans, Klebsiella pneumonia and Staphylococcus aureus. In our study, the antimicrobial activity of Garlic was found to be highest against Escherichia coli, Proteus vulgaris and Staphylococcus aureus. This study revealed the potential antimicrobial activities of Garlic. We concluded that the Garlic sample have a potential antimicrobial activity which can be used to develop alternate strategies to combat the challenges in pharmaceutical sciences.

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